ABSTRACT
This chapter describes trade name, classification, approved Indications for psychological disorders, available dosage forms, storage, and compatibility, usual dosage and administration, and clinically significant drug interactions of Sertraline. The exact mechanism of sertraline’s antidepressant and other related actions has not yet been fully determined. These actions appear to be directly related to sertraline’s ability to selectively inhibit the neuronal re-uptake of serotonin. Sertraline is relatively well absorbed following oral ingestion. Sertraline pharmacotherapy commonly has been associated with delayed ejaculation, diarrhea, dizziness, dry mouth, dyspepsia, headache, insomnia, nausea, somnolence, sweating, and tremor. Signs and symptoms of sertraline overdosage include anxiety, dilated pupils, nausea, somnolence, tachycardia, and vomiting. Sertraline overdosage requires emergency symptomatic medical support of body systems with attention to increasing sertraline elimination. Sertraline may displace from their binding sites other drugs that are highly bound to plasma proteins.
