Methotrimeprazine [Levomepromazine]

This chapter describes trade name, classification, approved indications for psychological disorders, usual dosage and administration, relative contraindications, clinically significant drug interactions, adverse drug reactions and overdosage of Methotrimeprazine. Methotrimeprazine is excreted into breast milk. Avoid prescribing methotrimeprazine pharmacotherapy to women who are breast-feeding. Methotrimeprazine’s analgesic action appears to be related to its ability to raise the pain threshold. Methotrimeprazine has analgesic and strong antiapomorphine, antispasmodic, and antihistaminic actions. Methotrimeprazine pharmacotherapy and concurrent pharmacotherapy with opiate analgesics, sedative-hypnotics, or other drugs that produce CNS depression may result in additive CNS depression. Methotrimeprazine pharmacotherapy has been associated with the following ADRs, listed according to body system. Signs and symptoms of acute methotrimeprazine overdosage include convulsions, CNS depression, spasms, tonic or clonic convulsions, tremor, and coma with hypotension and respiratory depression. Methotrimeprazine overdosage requires emergency symptomatic medical support of body systems with attention to increasing methotrimeprazine elimination.