ABSTRACT
This chapter describes trade name, classification, approved indications for psychological disorders, usual dosage and administration, relative contraindications, clinically significant drug interactions, adverse drug reactions and overdosage of Molindone. Molindone is absorbed rapidly and metabolized extensively after oral ingestion, with peak blood levels occurring within 1 hour. It is distributed widely in the body. Molindone is metabolized extensively in the liver to over 30 different inactive metabolites. Caution patients who are receiving molindone pharmacotherapy against performing activities that require alertness, judgment, and physical coordination until their response to molindone pharmacotherapy is known. Drowsiness commonly has been associated with the initiation of molindone pharmacotherapy. This ADR generally can be managed with continued pharmacotherapy or by lowering the dosage. Molindone pharmacotherapy also has been associated with depression, euphoria, and hyperactivity. Molindone overdosage requires emergency symptomatic medical support of body systems with attention to increasing molindone elimination.
