This chapter describes trade name, classification, approved indications for psychological disorders, available dosage forms, storage, and compatibility, usual dosage and administration, relative contraindications, and clinically significant drug interactions of Oxymorphone. Safety and efficacy of oxymorphone pharmacotherapy for women who are pregnant have not been established. Avoid prescribing oxymorphone pharmacotherapy to women who are pregnant. If oxymorphone pharmacotherapy is required, advise patients of potential benefits and possible risks to themselves and the embryo, fetus, or neonate. Collaboration with the patient’s obstetrician is indicated. Generally prescribe lower dosages of oxymorphone for elderly, frail, or debilitated patients. Increase the dosage gradually according to individual patient response. Oxymorphone pharmacotherapy with the rectal suppositories also may be of benefit for elderly, frail, or debilitated patients who may require a potent, rapid acting analgesic and generally are unable to tolerate oral or injectable opiate analgesic pharmacotherapy. Concurrent alcohol use may increase the CNS depressant action of oxymorphone.