ABSTRACT
This chapter describes trade name, classification, approved indications for psychological disorders, available dosage forms, storage, and compatibility, usual dosage and administration, relative contraindications, and clinically significant drug interactions of Paroxetine. If paroxetine pharmacotherapy is required, advise patients of potential benefits and possible risks to themselves and the embryo, fetus, or neonate. Collaboration with the patient’s obstetrician is indicated. Paroxetine is excreted in breast milk in concentrations equal to those found in maternal blood. Avoid prescribing paroxetine pharmacotherapy to women who are breast-feeding. Generally prescribe lower dosages of paroxetine for elderly, frail, or debilitated patients and those who have significant kidney or liver dysfunction. The exact mechanism of paroxetine’s antidepressant and other related actions has not yet been fully determined. These actions appear to be directly related to paroxetine’s ability to inhibit selectively the neuronal re-uptake of serotonin.
