ABSTRACT

Ethotoin is rapidly absorbed from the GI tract following oral ingestion. However, the extent of ethotoin’s absorption and bioavailability has not been determined. Ethotoin is extensively metabolized in the liver. Only a small percentage is excreted in unchanged form in the urine. Ethotoin is excreted in breast milk. Generally prescribe lower dosages of ethotoin for elderly, frail, or debilitated patients. Gradually increase the dosage if needed, according to individual patient response. These patients may be more sensitive to the pharmacologic actions of ethotoin than are younger or healthier adult patients. The signs and symptoms of ethotoin overdosage include coma, dizziness, fatigue, hallucinations, hypotension, incoordination (ataxia), insomnia, motor restlessness, nausea, and vomiting. Ethotoin overdosage requires emergency symptomatic medical support of body systems with attention to increasing ethotoin elimination.