ABSTRACT
The chapters dealing with model experiments of Attention Deficit Hyperactivity Disorder (ADHD), by definition requiring a psychobiological approach, encompass a vast collection of procedures, techniques and methods that may, either explicitly or implicitly, be applicable eventually as animal models for the derivation of new therapeutic agents. A basic assumption is that model experiments must bear an intimate relationship to animal models of disease states, whether it be as the initial step or as the consequence of the problem, and the two terms will henceforth be used synonymously. Animal models involve some need to describe/understand the etiology of the disease state. In the following chapters it is noted that the terms animal models and model experiments are used analogously to some extent. The chapters by Sagvolden and coworkers, Archer, Beninger and Thompson offer us animal experiments that address either the hyperactive state or the cognitive deficiencies or both. In ADHD research there appears to be a special requirement for the consideration of the animal models (in the loose usage of the term) currently available. A few of these models (and/or model experiments) are described in the following chapters by Terje Sagvolden and coworkers, Trevor Archer, Richard Beninger and Richard Thompson while the chapter by Bennett and Sally Shaywitz (this volume, see chapters on clinical aspects) centers upon the more fundamental issues of how, when and where to apply an animal model of ADHD. This latter orientation leads to questions regarding both the generality and sufficiency of the procedures described by the former three chapters. Thus, it seems fruitful and necessary to review other animal models of the ADHD syndrome.
