This chapter explains the use of psychological theory within a nursing framework to guide them how to assess lifestyle behaviours of patients with Safer sex in day-to-day clinical practice. Safer sex practices go beyond just the use of condoms. By knowing about and practising safer sex, the risks of getting a sexually transmitted infection can be significantly reduced. Sexually transmitted infection symptoms such as, Chlamydia, Genital warts, Genital herpes, Gonorrhoea, Syphilis, Trichomoniasis, Thrush, and HIV. Safer sex refers to those sexual activities that do not involve the exchange of bodily fluids semen, pre-ejaculation fluid, vaginal fluid and blood between one person and another. Use of condoms during penetrative sex for vaginal and anal intercourse, latex condoms should be used with water-based lubricants. Perceived barrier and proposed intervention strategy such as, Decreases sexual pleasure or sensation, Decreases spontaneity of sexual activity, Embarrassing, juvenile, 'Unmanly' and Fear of breakage may lead to less vigorous sexual activity.