A recent study involving 271 inﬂ ammatory bowel disease (IBD) patents indicated that within the ﬁ rst 2 months of diagnosis, 78 per cent identiﬁ ed attaining information about the risk of developing cancer as ‘very important’. However 73 per cent of this cohort identiﬁ ed receiving ‘none or little’ information about cancer and cancer risk associated with IBD, and only 8 per cent of patients perceived receiving the ‘right’ amount of information (Wong et al. 2012). Even after 10 years of diagnosis, 53 per cent of the cohort identiﬁ ed that they had not received or attained helpful information in relation to the risk of developing cancer associated with IBD (Wong et al. 2012). This chapter will review the rates of cancer and mortality associated with IBD, predictive and protective factors associated with cancer in IBD, and the psychosocial distress and common psychosocial concerns raised by individuals, partners and family members in relation to cancer and IBD.