ABSTRACT
Microorganisms belonging to Bacillus spp are considered as biofactories for producing biologically active compounds that potentially inhibit growth of phytopathogens. Fungi are major causative agents in plant diseases which lead to radical reductions in crop yield and cause economic loss to a country and its farmers. The antifungal lipopeptides are found to be involved in biocontrol activity against various phytopathogens such as fungi and bacteria that infect plants and crops. The Bacillus genus possesses a characteristic feature of producing a wide spectrum of secondary metabolites with antibiotic activity and diverse structures. Ligand discovery for the interpretation of the key biological process of ligand-drug interaction is performed at molecular level. Molecular docking analysis is done in order to depict the mode of action of surfactin, where the interaction of surfactin is depicted with the ligand leucine.
