ABSTRACT
Peritoneal disease morphology from colorectal cancer progression commonly may involve peritoneal metastases in the vicinity of the primary malignancy or over the right hemidiaphragm, the pelvic peritoneum and the ovaries. Metastatic spread in colorectal cancer occurs via the systemic, portal or peritoneal route. The main limiting treatment factor in pseudomyxoma peritonei is small bowel involvement, which will prevent complete tumour removal and is generally also the cause of death from pseudomyxoma with obstruction and intestinal failure. The definition of pseudomyxoma peritonei refers to the intraperitoneal accumulation of mucin secondary to mucinous neoplasia that is characterised by the redistribution phenomenon. Pressurized intraperitoneal aerosol chemotherapy involves a laparoscopy, peritoneal biopsies and administration of pressurised aerosol chemotherapy in the peritoneal cavity. In the future practice of personalised medicine, chemotherapy and immunotherapy will be directed by the tumour biology rather than extrapolating treatment protocols from colorectal cancer to appendix tumours simply because of their common embryological origin.
