ABSTRACT
Foreign antigens need to be processed and presented to T cells before the T cells can act on them and activate cell mediated immunity. The antigen is processed and presented by major histocompatibility complex (MHC) molecules on the surface of antigen presenting cells (APCs) to the T cells where the processed antigens are the recognised by the TCR complex on T cells, enabling signalling reactions to remove the pathogen. In this chapter, we discuss the MHC molecules and their involvement in antigen processing and presentation, and we also discuss the application of computational immunology in understanding the complexity of antigen presentation.
