ABSTRACT
Animal experiments are indispensable for the study of mycoses as well as other infectious diseases. Until now, various animal models of mycoses have been reported in the field of medical mycology. The granulomatous tissue covering the inoculum is slit open with a scalpel blade and the exposed agar block is put into a drop of a lactophenol solution on a glass slide. The pathogenic fungi are classified into two categories according to their parasitic forms. The first consists of the fungi which are mycelial in a saprobic life and spherical in a parasitic one. The second consists of the fungi whose parasitic forms are similar to the saprobic forms. When arthroconidia, prepared from slants, were inoculated intravenously into mice, the liver was severely affected by them, followed by the spleen, lung, and kidney in that order. When young hyphae of S. schenckii were implanted into the abdominal cavity of a mouse, yeast cells were consecutively produced from hyphae.
