ABSTRACT
Emulsomes described differ from liposomes since their internal core is a hydrophobic fat compartment, while in liposomes the internal core is an aqueous compartment. In liposomes, drugs can be either encapsulated in the enclosed aqueous space or intercalated into the lipid bilayer. The combination of the specific lipid composition and manufacturing technology resulted in stable lipid particles in the nano-size range. The parameters most frequently used to characterize lipid particles are morphology, particle size and size distribution, lamellarity, and trapped volume. The particle size distribution of Emulsome formulations were determined by photon correlation spectroscopy, based on measuring laser scattered-light fluctuations, using a N4MD Coulter submicron particle size analyzer working at the differential weight % operation mode of the instrument. Negative stain electron microscopy has been used to characterize the morphology, size, and shape of the lipid particles present in phospholipid dispersions.
