ABSTRACT
Approaches were realized to prepare synthetically androgens and anabolics with more advantageous properties than testosterone alone. In newly synthetized compounds an interesting fact was observed that, in the various derivatives of basic androstane skeleton, the ratio of anabolic and androgenic effect was different even when both effects were present in all effective compounds. In the field of androgens and anabolics there are many more empirical findings about the structure-activity relationship than quantitative structure–activity relationship computer studies. A. K. Ghose and G. M. Crippen explained a three-dimensional representation of molecular structure by the term "distance geometry". To understand the interaction between androgens and receptor macromolecules in the target organs, it is important to consider topographic and steric relations in the androstane skeleton. The chemical structure can be considered also as a property, so that structural characteristics are qualitative parameters and structure is a sum of substructure elements together with the type of characteristics common for all compounds of an estimated set.
