ABSTRACT
Entrapment of cytotoxic drugs inside endocytizable carriers such as liposomes improves the specificity of the drug and reduces its toxicity towards non diseased cells. Work in this field has resulted in the development of polyacrylamide nanocapsules. The major advantage of alkylcyanoacrylates over other acrylic derivates which were previously used in the preparation of submicroscopic nano particles lies in the polymerization process of monomers. Unlike other acrylic derivates, the polymerization of which requires an energy liable to hinder the good adsorption of the drug, alkylcyanoacrylates may be polymerized without that energy. Polyalkylcyanoacrylate nanoparticles (PAN) were prepared with and without using surfactive agents at various pH ranging between pH 2.9 and 4.1. The molecular weights of these preparations were determined by an HPLC-GPC chromatography on a Styr-agel column. The drugs to be adsorbed onto the carrier can be dissolved in the polymerization medium before the addition of the alkylcy-anoacrylic monomer or in the already prepared nanoparticle suspension.
