Phosphorylation of Phosphofructokinase — The Possible Role of Covalent Modification in the Regulation of Glycolysis

Fructose-1,6-bisphosphate was the first phosphorylated intermediate of glycolysis whose existence was detected. ¹ The enzymatic reaction leading to its formation was formulated 30 years later as follows: (1) Fructose-6-phosphate   +   ATP   →   Fructose-1,6-bisphosphate   +   ADP   +   H + https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781351076265/d5a053df-2a9e-4445-abdf-39fa1895d57c/content/eq8.tif"/>