ABSTRACT
Antiphospholipid syndrome (APS) is associated with the presence of antibodies to negatively charged phospholipids. Primary APS was induced by immunization with different anticardiolipin antibodies (aCL). Passive transfer of aCL to mice and induction of APS were carried out by injecting naive mice either intraperitoneally or intravenously with IgG purified from patients with APS. Aspirin and interleukin-3 were effective agents in preventing the manifestations of experimental APS. Interleukin-3 capable of increasing platelets number both in vitro and in vivo due to a de novo production of megakaryocytes. I. Krause et al. have demonstrated the efficacy of low-dose aspirin in preventing fetal resorptions, shortening activated partial thromboplastin time, and leading to increased placenta and embryo mean weights. Cytokines were found to have numerous roles in normal and pathological processes of reproduction and pregnancy. Higher doses of aspirin had no effect on the cytokine production.
