ABSTRACT

The interstitial cells of the ovary were also found to contain the vitamin; the ascorbic acid concentration of the corpus luteum was highest when that organ was mature and decreased as it involuted. Loh and Wilson observed a pattern of urinary total ascorbic acid (TAA) excretion during the menstrual cycle, somewhat similar to that of Pillay and others, in first morning urine samples from women receiving 500 mg of ascorbic acid every morning at breakfast. They found no difference in the disappearance rates of ascorbic acid from the serum after intramuscular injections of ascorbic acid AA given in the follicular, ovulatory, or luteal phases of the menstrual cycle. Studies by Hoch-Ligeti and Bourne (1948) revealed that rat ovaries show cyclic changes in the concentration and histological distribution of ascorbic acid during the estrus cycle; the ascorbic acid content and concentration of the ovaries were lowest at estrus.