ABSTRACT
In the early and mid-1970s it was discovered that cis-diamminedichloroplatinum (11) (cisplatin or CDDP) could potentiate the effects of ionizing radiation (DXT).1.2 Since that time there have been numerous studies carried out on mammalian cells in vitro, in experimental animal tumors, and in several normal tissue models which have confirmed these
This chapter reviews some of these data in an attempt to assess the potential value of CDDP-DXT interactions and to suggest ways in which such combined modality therapy could be improved.
