ABSTRACT
IV . Future Development. Directions. and Uses ..................................... 182 A . New Analogs ............................................................ 182 B . Pharmacological Modulations ........................................... 182 C . New Drug Design ....................................................... 182
V . Summary ....................................................................... 183
.............................................................................. References 184
A. IMPORTANCE OF PLATINUM COORDINATION COMPLEXES IN CANCER CHEMOTHERAPY
1. Historical Background The antitumor activity of the neutral platinum coordination complex cis-diamminedi-
chloroplatinum(II), or cisplatin (CDDP), was first reported in 1969 by Rosenberg and colleagues' using Sarcoma 180 and L1210 murine tumors. This report, and the demonstrated effectiveness of CDDP in other animal turn or^,',^ stimulated extensive interest in the chemistry of this relatively simple inorganic molecule and introduced an important role for this class of metalloorganic complexes in cancer chemotherapy.
