ABSTRACT
Since acrodynia was one of the earliest recognized symptoms of B6 deficiency, cure of this dermatitis was quickly adapted as a test of B6 activity. The B6-deficient diet was continued for another 12 to 16 days at which time the animals were sacrificed. Each animal received a B6-deficient diet supplemented with 100 gg deoxypyridoxine per day. Emerson was the first worker to extend Ott's report of B6 antagonism in chicks to rats. Whereas the rat has been studied quite thoroughly, most of the work in mice has been limited to observations of gross toxicity. Pfeiffer noted that 1.5 mmol deoxypyridoxine per kilogram was a sure convulsant dose in mice. Tsunoo et al., reported that the brain serotonin level in rats was not altered during convulsions induced by deoxypyridoxine at a dose of 400 mg/kg subcutaneously. Nelson and Evans continued their study of deoxypyridoxine effects in reproduction in rats.
