ABSTRACT
Since 1970 considerable attention has been focused on the environmental distribution and the potential hazards of the polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). The mixed tetrahalogenated dibenzo-p-dioxins synthesized were also characterized by gas chromatographic/mass spectrometric (GC/MS). Bromocatechols needed as intermediates in the synthesis of halodibenzo-p-dioxins were synthesized either by direct bromination of catechol or by the Dakin reaction of bromo-substituted salicylaldehydes. The mass chromatogram obtained for 1,3-dichloro-7,8-dibromodibenzo-p-dioxin. The electron capture/GC (EC/GC) system used to analyze the Polybromodibenzo-P-Dioxins was a Varian 3740 GC equipped with an electron capture detector (GC/ECD). The Tetrabromodibenzofurans were synthesized by the palladium-catalyzed cyclization of bromo-substituted diphenyl ethers. Preliminary evaluation of the biological activities of the halogenated dioxins was accomplished using a chick embryo model, and the results of the study generally agree with the conclusions of Kende et al.
