ABSTRACT

Figure 1 illustrates the most essential and relatively well-studied ways of transforming the intermediates of the free-radical lipid peroxidation. For the sake of simplicity, all possible reactions of one type have not been presented, nor have all structural and positional isomers of the LP0 products. Moreover, a large number of components formed in vitro and in vivo by the interaction of intermediate LP0 products with intracellular components (e.g., with antioxidants) are not considered at all as they are not sufficiently studied, with the exception of lipofuscin-like fluorescent pigments. A more detailed description of the mechanisms of the reactions involving the participation of intermediates of free-radical oxidation of lipids is given in References 1 to 6.