ABSTRACT
This chapter investigates the effect of varying inhaled concentrations of methyl chloroform on cardiac as well as on systematic vascular and pulmonary vascular functions in anesthetized intact dog preparations. A special effort was made to determine the minimal concentration of methyl chloroform which influences cardiac function, systemic vascular resistance, and pulmonary vascular resistance. Since methyl chloroform is likely to be used with a fluorocarbon propellant in aerosol products, the experiments were designed to determine if there was any interaction between methyl chloroform and one of the more commonly used fluorocarbon inhalants, trichlorofluoromethane. In general, a dose-related cardiovascular depressant action was exhibited by methyl chloroform. The most outstanding effect of methyl chloroform, in fact an effect which appears with the minimal effective concentration, is a decrease in systemic arterial pressure and in cardiac output. The effect of methyl chloroform on the pulmonary component of the cardiovascular system deserves a comment.
