ABSTRACT
Extensive research has been pursued with extended-release drug delivery systems. The advantages of such systems over traditional dosage forms include less frequent dosing, improved patient compliance, and more stable blood levels of the drug, which can significantly increase the efficacy and reduce the side effects of the drug substance. advances in the field of drug delivery have resulted in the precise control of the level and location of drug delivery in the body. Polymers and hydrophobic lipids can be used as both binders and retardants. The most widely used processes to manufacture extended-release oral dosage forms include the wet granulation, dry granulation, and direct compression techniques. This chapter describes the drug release mechanism of extended-release dosage forms, and the application of the twin-screw extrusion process to prepare various extended-release dosage forms. It discusses the mechanisms for matrix formation during the extrusion process. The chapter presents the advantages and challenges of twin-screw processes.
