ABSTRACT
Nanoparticles have an interesting surface chemistry and are used in a wide variety of applications ranging from consumer products like socks, medical dressings, and computer chips. They have also been shown antimicrobial, anti-bacterial activity and wound healing properties. The small size of the particles makes nanotechnology so useful for the drug delivery system, but this small size is also one of the main factors that make them a potential threat to human health. Nanomedicines have played a very important role in the field of diagnosis and therapy in the past decade and still continue to be an important element of success in the field of medicine. The effect of nanoparticles on the proliferation and differentiation of stem cells has been studied under regeneration medicine and material science. However, advances in nanotechnology innovation related to stem cell biology and cell reprogramming remain less progressive. It is very crucial to study the cell-nanoparticle interactions in depth to eradicate any negative effects of the nanoparticles. The cellular toxicity of nanoparticles has been extensively studied in Mesenchymal-epithelial stem cells (mESCs) and human mesenchymal stem cells (hMSCs). Investigations purporting to study the toxicity of metal particulates are still in their infancy at this time and have concentrated on revealing the toxicity, tissue distribution, and antibacterial properties of metallic nanoparticles, and in addition the tissue distribution and cellular uptake of gold nanoparticles. Therefore, more study is needed to understand the role of these nanoparticles on human health.
