ABSTRACT
Nanofibers are one of the nano-architectural materials that are much stronger, lighter, cleaner and ‘smarter’ surfaces and systems than ever known earlier. They are widely used in engineering, defence, filtration, scaffolds, separators, devices and sensors. Nanofibers, because of their interesting features, including surface-to-volume ratio, high surface area, micro-porosity and non-woven structure, provide numerous opportunities to design novel carriers for large therapeutic commodities. Several process and formulation parameters are important to make nanofibers, including applied voltage, flow rate, polymer selection and concentration of polymer used. Applications of nanofibers in drug delivery are nearly limitless. This book chapter provides an overview of nanofibers, encompassing their preparation, characterization and role in developing more effective novel drug-delivery systems.
