ABSTRACT
Dendrimers represent three-dimensional, hyper-branched, multi-functional nanopolymeric structures having immense potential for targeted drug delivery. The unique structures and properties offered by these nanocarriers constitute the key factors contributing to their smart drug delivery characteristics and excellent solubilization capabilities. Recent past has witnessed a large volume of dendrimer-driven research publications, patents and commercial formulations based on dendrimers. Mostly, polyamido amine (PAMAM) dendrimers have been extensively explored for drug delivery and other biological applications, though other classes of dendrimers have also been claimed to possess high potential. Of late, the applicability of these cationic PAMAM dendrimers and others has been successfully explored as gene delivery vehicles as well. Dendrimers are also the gold standard as non-viral vectors for siRNA and other polynucleotides across the cell membrane. Custom-made functionality at the surface of dendrimers allows researchers to design the dendrimers according to the application needed, while the hydrophobic interior has been responsible for excellent solubilizing properties of the dendrimers. The present chapter endeavors to encompass an account of the key properties, types, characterization, synthesis and applications of dendrimers as a promising carrier in drug delivery and solubilization.
