ABSTRACT
Nanotoxicology belongs to one of the emerging interdisciplinary scientific areas and is concerned with the risks, adverse effects and the potential toxicity resulting from the exposure to nanomaterials. Over the past few years, microfluidic technology, in combination with microscale culture of cells, has shown great potential for designing and establishing physiologically-relevant analytical techniques for nanotoxicity examinations. In the present chapter, we focus on state-of-the-art applications in microfluidics-based screening platforms and cytotoxicity assays for nanotoxicological studies. We highlight, in particular, the noticeable advantages of microfluidic devices in view of tackling a multitude of the prevailing challenges experienced with conventional toxicological assays and recreating in vitro models at a more physiological scale for nanotoxicity examinations.
