ABSTRACT
For decades, neurodegeneration has been one of the major challenges faced across the globe. Intensive research has therefore been focussed on unearthing the mechanisms involved in the etiology, epidemiology, and pathogenesis of the diseased states. Various therapeutic and surgical strategies have been put into practice, but with varying degree of success. Use of nanomedicines has lately emerged as a promising solution to the scourge of the neurodegenerative disorders. This tends to encompass the development of appropriate nanocarriers such as lipidic, polymeric, metallic, and hybrid nanosystems of drugs and bioactives, especially those which pose difficulty in crossing the blood–brain barrier (BBB). Some promising bioactives, in this context, encompass quercetin, rutin, resveratrol, and curcumin. Use of such bioactives for the management of neurodegeneration is a promising approach, accomplished using nanotechnology. As such nanoscaled systems show a remarkable resemblance with the biomolecules, these can serve as potential tools in the management of the neurodegenerative disorders.
