ABSTRACT
Erythroderma as a clinical entity in dermatological practice is a must-know condition, and one should be well versed in its approach and management. The chapter aims at providing an insight especially in clinical approach, identifying and differentiating the underlying states, potential mortality and morbidity associated with erythroderma, and the approach in managing the condition. It is important to establish the underlying cause in every possible case to facilitate precise management. A detailed history of triggering agents, preexisting dermatoses, topical and systemic medications, and associated comorbidities are essential prerequisites in erythroderma. In recalcitrant states, always consider underlying malignancy and thorough evaluation, including flow cytometry, immunophenotyping, and T-cell clonality studies. All cases should be considered as an emergency by rule and hospitalized in an intensive care setup. Potential complications include infection, dehydration, electrolyte imbalance, temperature dysregulation, and high-output cardiac failure. If initial management is promptly undertaken, the morbidity and mortality can be reduced significantly.
