ABSTRACT
Staphylococcal scalded skin syndrome is a spectrum of superficial blistering disorders caused by an exfoliative toxin of Staphylococcus aureus. In the generalized variant, following a prodrome there is a scarlatiniform eruption that eventuates into formation of flaccid bullae leading to erosions and exfoliation that is more prominent over the flexures. Due to the high level of split in the epidermis, there is rapid healing with appropriate treatment usually within 10 days. Investigations are directed toward identifying a potential focus of staphylococcal infection, fluid status of the patient, and any evidence of secondary infection. The primary focus of infection is obscure in children but is detectable in adults in most cases. Hospitalization of the patient with administration of fluids to maintain electrolyte and fluid balance, infection control with antibiotics, and pain management are the mainstay of treatment. Mortality is low in children but is higher in adults on account of an associated immunocompromised state.
