ABSTRACT

Department of Pathology, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA, E-mail: Chandrani Sarkar: Chandrani.Sarkar@osumc.edu, Debanjan Chakroborty: Debanjan. Chakroborty@osumc.edu

Abstract .....................................................................................................114 4.1 Introduction ......................................................................................114 4.2 Importance of Angiogenesis During Tumor Growth .......................115 4.3 Process of Neovascularization .........................................................117 4.4 How Is Tumor Vasculature Different from Normal Vasculature? ....118 4.5 Key Regulators of Angiogenesis ......................................................119 4.6 Antiangiogenic Therapy ...................................................................137 4.7 Advantages of Antiangiogenic Therapy and Complications ............143 4.8 Resistance to Antiangiogenic Drugs ................................................147 4.9 Conclusion .......................................................................................148 4.10 Summary ..........................................................................................149 Acknowledgments .....................................................................................150 Keywords ..................................................................................................150 References .................................................................................................150

ABSTRACT