ABSTRACT
Cardinal Isidore left the haven of Crete, presumably when he had somehow recovered from his adventures, in late summer or early fall of 1453 and returned to Italy. Apparently, he felt concerned and isolated on the island, as he indicates in one of his letters; he wrote to Capranica in July of that year and expressed his anxiety, because he had received no reply(ies) to his letter(s). The last surviving letter of Isidore with regard to the fall of Constantinople is his epistle to the duke of Burgundy, dated the 22nd of February 1455, Data Romae die XXII Februarii MCCCCLo quinto. While this letter provides no new information to what the cardinal had earlier written in Crete, it does address the point of the official position of Genoa during the siege, a matter that was of concern to the Genoese and to their colony at Pera.