ABSTRACT
This chapter describes the preparation of fused five-membered nitrogen heterocycles through palladium (Pd) assisted reactions. For more than a century, heterocyclic compounds are the largest classical divisions of organic chemistry with industrial and biological importance. Heterocycles have contributed to the understanding of life processes as well as to industrial and biological development. By the end of second millennium among 20 million chemical compounds identified, more than two-thirds at partially or fully aromatic and approximately half are heterocyclic compounds. For the synthesis of heterocycles many new protocols have been developed which involved Pd-catalyzed carbon-nitrogen bond-forming reactions. Pd -catalyzed carboamination of alkenes has become a useful method for the synthesis of a broad array of nitrogen-containing heterocycles. In addition, intramolecular aminopalladation process has been demonstrated as a preferred route for the synthesis of valuable nitrogen heterocycles. Fused bis(heterocycles) were prepared by alkene aminopalladation/carbonylation.
