ABSTRACT
Many nitrogen (N)-heterocycles were synthesized when nitrogen-centred nucleophiles were reacted with α,β-unsaturated ketones. Carboxylate-substituted imidazolines are biologically relevant heterocycles, formally incorporating an amino acid residue into heterocyclic core. The cyclic ureas and similar heterocycles were produced by reactions of vinylaziridines or activated vinylcyclopropanes with isocyanates and other heterocumulenes. The heterocycles were produced via intra- and intermolecular carbon-heteroatom bond forming reactions with alkenyl aziridines. Imidazoles constitue a useful class of heterocycles found in a diverse variety of pharmaceutically relevant products. Subsequently, a five-membered ring cyclization led to polysubstituted imidazolidinones in rather excellent selectivity and good yields. A non-oxidative approach toward the asymmetric synthesis of N-heterocycles was palladium(II)-catalyzed alkene aminopalladation involving substrates bearing allylic acetates. Imidazoles constitue a useful class of heterocycles found in a diverse variety of pharmaceutically relevant products. A variety of heterocycles were obtained from o-nitroaromatics by reductive N-heteroannulation with transition metal catalyst.
