ABSTRACT

When the first edition of The Natural History of Rabies was published in 1975 the cultivation of rabies virus in cell cultures was already widely used for the study of the cell-virus relationships, the production of large amounts of purified virus, and soon after, for the preparation of new cell culture rabies vaccines. Nevertheless, cell cultures were not, at that time, used for street rabies virus isolation and were not included among the methods proposed or recommended for rabies laboratory diagnosis.