ABSTRACT
In this chapter, we present an overview of the mechanisms involved in the toxicity of magnetic nanoparticles (MNPs), focusing on the generation of oxidative stress and degradation of the nanoparticles (NPs) in physiologically relevant conditions. These mechanisms are then discussed in function of the contribution of NP-specific parameters, including the chemical composition of the core, the chemical nature of the surface coating, the size and shape of the NPs and the conditions under which the NPs were used (time, concentration, etc.). Based on these data, we present an outlook on how, in the future, this field will further develop and pave the way for the future exploitation of MNPs in a wide range of biomedical applications.
