ABSTRACT
Magnetic nanoparticle-based hyperthermia (MHT) is one of the first nanotechnology applications to be introduced in the clinical practice for cancer treatment. In this chapter, we discuss the mechanisms of heat generation by magnetic nanoparticles (MNPs) when exposed to an alternating magnetic field. We highlight the challenges associated with characterizing the heating efficiency of MNPs in the intracellular environment. Finally, the use of MHT in combination with other cancer therapeutic modalities such as radio- and chemotherapy are reviewed, focusing on clinical applications.
