ABSTRACT
A wide variety of drugs from many different pharmaceutical classes have been associated with the development of vasculitis (Table 1). These vasculitides range from cases of self-limited leukocytoclastic vasculitis to reports of chronic, life-threatening, systemic necrotizing vasculitis. However, due to problems with classification of drug-induced vasculitis (DIV) and the inherent difficulty in proving causality between particular agents and specific adverse drug reactions, the quality of supporting evidence for drugs that cause vasculitis vary from data from large clinical trials to animal models of disease to individual case reports. This chapter describes the clinical and pathological spectrum of vasculitides putatively ascribed to adverse drug reactions and outlines the evidence supporting these associations.
