ABSTRACT
It is now more than 60 years since the rst nuclear magnetic resonance (NMR) signals were detected independently by the groups of Bloch and Purcell. Since then, NMR has been developed into the most important structural analysis tool available in organic chemistry. Its applications range far and wide, from determination of protein structures in solution and the study of oils in the petrochemical industry to sophisticated NMR imaging methods in clinical studies. Until recently, its use in drug metabolism groups was relatively unusual. This is probably because NMR was historically found in
13.1 Introduction ......................................................................................................................... 261 13.2 Basic Theory of the NMR Phenomenon ............................................................................. 262 13.3 Parameters of the NMR Spectrum ...................................................................................... 263
13.3.1 Chemical Shift ....................................................................................................... 263 13.3.2 Spin-Spin Coupling ...............................................................................................264 13.3.3 Intensity..................................................................................................................268
