ABSTRACT
The bioanalyst, whether involved in the quantitative analysis of drug-related components or the isolation and identication of metabolites, faces signicant challenges. In most cases, a successful bioanalytical process will require the isolation of drug-related material from complex biological matrices, such as plasma, urine, or faeces, the separation of the compounds of interest from other drug-related components or from residual endogenous material and the detection of analytes, often at very low levels. Furthermore, accuracy, precision, and speed are often prerequisites in the modern era. This chapter provides an introduction to the physicochemical properties of drugs and
1.1 Introduction .............................................................................................................................1 1.1.1 The Challenge for the Bioanalyst.................................................................................1 1.1.2 The Scale of the Challenge ..........................................................................................2 1.1.3 The Impact of Physicochemical Properties .................................................................2
