ABSTRACT
Studies..................................................... 289 10.3 Drug Release from Bulk Nondispersed Cubic
Phase in Relation to Cubosomes....................................... 290 10.4 Studies of Drug Release from Cubosomes
in This Laboratory.............................................................. 293 10.4.1 Dialysis as a Method for Measuring
Drug Release from Cubosomes........................... 293 10.4.2 Pressure Ultrafiltration-A Proposed
Method for Measuring Drug Release from Colloidal Particles Such As Cubosomes ............. 294 10.4.2.1 Release of Lipophilic Compounds ..... 296 10.4.2.2 Release of Hydrophilic Compounds... 298
10.5 The Future for Cubosomes as a Controlled-Release Delivery System.................................................................. 300
10.6 Conclusions ......................................................................... 301 Acknowledgments........................................................................... 301 References....................................................................................... 301
A drug delivery platform based on submicron particles, which can provide controlled release of drug after intravenous (IV) infusion, has been the subject of much research in recent decades. Despite some success with long-circulating liposomes providing a means of controlling the release of some hydrophilic drugs (1), the ideal controlled-release injectable delivery system that operates independently of drug properties has not been achieved to date.
