ABSTRACT
Release from Monoglycerides ............................................ 332 12.6 Binding of Various Drugs to Monoglycerides ................... 335 12.7 Effect of Drugs on the Phase Transition
of Monoglycerides ............................................................... 338 12.8 Pharmaceutical Application of Monoglyceride-Based
Extended-Release Dosage Forms ...................................... 339 12.8.1 Oral Delivery ........................................................ 339 12.8.2 Topical Delivery.................................................... 342 12.8.3 Depot Drug Delivery Systems ............................. 344 12.8.4 Dental Application................................................ 348 12.8.5 Ophthalmic Application ....................................... 348 12.8.6 Buccal Delivery..................................................... 349
12.9 Conclusion ........................................................................... 349 References....................................................................................... 350
Monoglycerides are esters of glycerol and fatty acids. Long-chain monoglycerides such as glyceryl monooleate (GMO) and monolinoleate (GML) are water insoluble but water swellable polar lipids. Upon swelling in water, monoglycerides form several mesophases. This property was first systematically studied by Lutton in 1965 [1]. GMO and GML swell into an inverted micellar phase (L
), a lamellar phase (L), and a viscous isotropic phase with increasing water content. Later, Hyde et al. reported that the viscous isotropic phase is a cubic phase, which consists of a curved bilayer extending in three dimensions separating two congruent networks of water channels [2]. Extensive studies have been reported by Larsson on the structures of GMO cubic phases [3].
