ABSTRACT

Biological Phenomenon under Investigation.....................................48 4.4.3 Step 3: Define the Extrinsic Factors Associated with the

Biological Phenomenon under Investigation such as the Epidemiology of the Disease.............................................................49

4.4.4 Step 4: Create a Search Strategy and Review the Literature of Previous Animal Models ...............................................................50

4.4.5 Step 5: Create a Biological Information Matrix ...............................51 4.4.6 Step 6: Define Unique Research Resources ......................................51 4.4.7 Step 7: Identify Preliminary Animal Models of Choice ...................54 4.4.8 Step 8: Conduct Research to Fill Critical Gaps of Knowledge