ABSTRACT

The human nervous system, its changes during development, adulthood, and old age, and its alterations with disease, represent one of the most challenging and intriguing studies of our time. Despite increasing and rapid advances in our understanding, we still have few direct answers to our many questions concerning the activities of its three major divisions, the peripheral, autonomic, and central nervous systems. Studies of the aging nervous system provide valuable information on aging processes

and nervous functions. Comparison of the adult and aging brain, with or without neurologic and psychiatric diseases of old age, reveal specific, morphologic, biochemical, and functional differences under normal and diseased states.