Sodium Lauryl Sulfate—Induced Irritation in the Human Face: Regional and Age-Related Differences

Although extensively studied (1), sodium lauryl sulfate (SLS) has been rarely used on the face to investigate mechanisms of irritation (2). Because of the particular skin sensitivity of the face and the neck and because of the regional variability in the face reactivity to watersoluble irritant compounds (3) and to compounds inducing contact urticaria (4,5), we conducted this study with SLS 2% under occlusion for one hour.