ABSTRACT
Macromolecules have gained interest as potential active entities and as modulators of percutaneous delivery systems. Some success in percutaneous delivery using enhancer is being reported, despite these compounds exceeding the “500 Dalton rule” (1). Another approach is to use macromolecules as transdermal transport facilitators, where the presence of macromolecules can interact at the skin surface that facilitates the passage of another chemical or drug (2). These macromolecules can interact at the skin surface, interphasing with cosmetic ingredients to alter the initial phase of percutaneous absorption, which is the initial partition into the skin.
