ABSTRACT
I. Introduction .....................................................................................................325 II. Hcy, Folate, and Cognitive Function in Older Adults ................................... 326
A. Methodological Considerations .................................................................326 1. Study Design ........................................................................................ 326 2. Assessment of Cognitive Function .......................................................... 327
B. Landmark Studies .................................................................................... 329 C. Folate, Hcy, and Alzheimer’s Disease ..................................................... 330 D. Folate, Hcy, and Cognitive Test Performance .......................................... 333 E. Folic Acid Treatment and Cognitive Function ......................................... 338
III. Hcy, Folate, and Depression ..............................................................................340 A. Background and Methodological Considerations ....................................340 B. Epidemiological Studies of Folate Status in Relation to Depression ....... 342
IV. Summary .........................................................................................................345 References .....................................................................................................346
